Adobe photoshop cs5 Installer failed to initialize

 sacn ur registry u have registry problems, and check ur system files,use registry cleaner reg in out to clean ur registry and system files

and download windows installer latest version from microsoft site 

Answered Sep, 16 2010

so strange, i have never met this error, but i can tell you some information about "Application failed to initialize" error. This error message is displayed because Windows Defender beta expired on the December 31, 2006. Now, when you try to launch this program beyond its expiry date, you may receive the error. and you can find tthe answer in this link, come on.......

source: http://windowshelp.net/windows-defender-help/application-failed-to-initialize-error.aspx

hope it can help you.

Answered Sep, 16 2010

Hi, you can do as follows:
1.Click Start - Control Panel - Double click Network and Internet Connections-Double click Internet Options.
2.On the IE properties windows you will see these Taps:General | Security | Privacy | Content | Connections | Programs |Advanced
3.Under General Tab clear your History, Internet Files and Cookies.
4.Click on Advanced tab and scroll down to under the Browsing Option:Browsing
5.Enable Third-Party browser extensions (Req Rest) uncheck this box.
6.Click on Programs Tab and click Manage Add-Ons and Disable all nonVerified Add-Ons.
Reference:
http://forums.techarena.in/windows-xp-support/588354.htm Answered Jul, 07 2011